Healing & Repair - RESEARCH DATA
TB-500
Molecular Weight
899.0 Da
Half-Life
~3 days (subcutaneous)
Peptide Sequence
LKKTETQ
TISSUE REPAIRACTIN BINDINGANTI-INFLAMMATORYFLEXIBILITY
TB-500 is a synthetic peptide derived from Thymosin Beta-4, a naturally occurring protein present in virtually all human and animal cells. The active fragment (LKKTETQ) is responsible for actin binding and tissue regeneration properties.
Research demonstrates significant effects on wound healing, muscle repair, and angiogenesis. TB-500 has been shown to promote cell migration and differentiation, making it a subject of interest in sports medicine and regenerative research.
Deeper Analysis
## Mechanism of Action
TB-500 binds to G-actin, sequestering actin monomers and regulating cell migration and differentiation. It promotes angiogenesis, upregulates the expression of metalloproteinase-2 (MMP-2), and reduces inflammation by downregulating inflammatory cytokines.
## Research Highlights
- Promotes cardiac tissue repair post-MI in rodent models
- Accelerates corneal wound healing
- Reduces fibrosis in liver and muscle tissue
- Enhances flexibility and reduces adhesions
## Dosing Notes (Research Context Only)
Common research protocols: 2-5 mg administered 1-2x weekly. Loading phase often employed for 4-6 weeks, followed by maintenance dosing.
## Half-Life & Stability
Longer half-life (~3 days) due to larger peptide structure. Stable lyophilized at -20C, reconstituted with bacteriostatic water.
Peer-Reviewed Citations
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