Healing & Repair - RESEARCH DATA

BPC-157

Molecular Weight

1419.5 Da

Half-Life

~4 hours (subcutaneous)

Peptide Sequence

GEPPPGKPADDAGLV

HEALINGGI TRACTANGIOGENESISTENDON REPAIR

BPC-157 is a pentadecapeptide derived from a protective protein found in human gastric juice. It has been extensively studied for its regenerative and cytoprotective properties across multiple tissue types including muscle, tendon, ligament, and gut epithelium.

Animal studies suggest accelerated wound healing via upregulation of growth hormone receptors and promotion of angiogenesis through the nitric oxide system. Gut-protective effects are particularly well-documented, with consistent findings across rodent ulcer models.

Deeper Analysis

## Mechanism of Action BPC-157 exerts its effects through multiple pathways. It upregulates growth hormone receptors in tendon fibroblasts, modulates the NO-system (nitric oxide), and promotes angiogenesis via VEGFR2 activation. It also interacts with the dopaminergic system, providing neuroprotective effects. ## Research Highlights - Accelerated Achilles tendon healing in rodent models (Sikiric et al., 2003) - Gastroprotective effects in NSAID-induced ulcers - Reduction of inflammation via NF-kB pathway inhibition - Improved muscle recovery after crush injury ## Dosing Notes (Research Context Only) Typical research dosing in rodents: 10-100 mcg/kg. Human extrapolation ranges discussed in biohacker literature: 200-500 mcg/day subcutaneous or intramuscular. Oral dosing also explored for GI applications. ## Half-Life & Stability Approximately 4 hours when administered subcutaneously. Peptide is stable in lyophilized form, should be stored at -20C after reconstitution.

Peer-Reviewed Citations

Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract

Sikiric P, Seiwerth S, et al. (2006) - Current Pharmaceutical Design

BPC 157 and Standard Angiogenesis Inhibitors

Sikiric P et al. (2020) - Current Pharmaceutical Design

Members-only content

Connect your Solana wallet to unlock full research articles, dosing protocols, stack guides, and community forum access.

No NFT required - Wallet signature only - Free access